Body composition analysis by NMR
The minispec LF Series is a Whole Body Composition Analyser based on TD-NMR that provides a precise method for measurement of lean tissue, fat, and fluid in living mice and rats. By carefully handling the animal without using any anaesthetics, a new standard for longitudinal studies has been established.
The minispec LF Series has quickly gained market acceptance as a powerful, non-destructive, and non-invasive mice analysis tool for characterising, screening and mouse phenotyping in research laboratories. It has become the industrial standard for fat and lean measurement in live mice with installations in major pharmaceutical companies, diabetes and obesity research institutes and universities.
Nuclear Magnetic Resonance (NMR) methods are among the most useful non-destructive techniques of material analysis. Non-invasive examination of the body by means of NMR is extensive and has many useful applications, particularly with Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS). TD-NMR uses similar NMR technology, providing analysis of fat tissue, lean tissue and free fluid by the same physical selection rules that give rise to contrast in MRI. Tissue contrast is high between fat and muscle based on relative relaxation times.
Features & benefits
The minispec LF Series enables researchers to perform multiple measurements during the life of the animal. Animals can be measured even every day, and the method is ideal for longitudinal studies.
- Non-invasive and non-destructive.
- Quantitative method.
- Rapid analysis: measurement takes less than 2 minutes, no sample preparation.
- Economical procedures:
- No consumables.
- Retain expensive lab animals for entire study.
- Reduced animal stress:
- No need for anaesthetics; no recovery time so minimal effect on metabolism.
- Animals are measured “as-is”.
- Allows more frequent testing, due to reduction of risks to animal health, even daily acquisitions.
- Operator requires no special NMR skills.
- Easy and intuitive minispec software.
- Long-term reliable and problem-free operation.
- Better accuracy and precision compared to DEXA (X-ray) method.
Specifications
- Maximum mass of mice:
- Mouse systems: LF50 for mice up to 60 g.
- LF90II: rats up to 700 g; mice, organs up to 130 g; biopsies 50 to … 500 mg.
- LF110: rats up to 1000 g; mice, organs up to 130 g; biopsies 50 to … 500 mg.
- Maximum inner diameter of the mice container: 48 mm.
- Accuracy and precision: about 1% of total mass.
- Calibration with standards, with animals or according to special user requirements.
- Measurement frequency: 7.5 MHz (LF50), 6.2MHz (LF90) and 5.7 MHz (LF110).
- User friendly interface for simple operation during measurement series.
- Microsoft Windows system for data acquisition combined with a Microsoft Access data base allowing safe data management without user labour effort.
- ISO 9001:2015 certified.
- CE conformity.
Documents
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